Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2002922 | 0.94 | MAPT (0.35) | HSD17B10PPARGMAPTTSHRMEN1 | |
| SCHEMBL2006095 | 0.93 | FAAH (0.39) | HSD17B10MAPTCYP3A4TSHRMEN1 | |
| SCHEMBL2009136 | 0.92 | MAPT (0.40) | HSD17B10PPARGMAPTCYP3A4TSHR | |
| SCHEMBL2001648 | 0.91 | RET (0.37) | MAPTCYP3A4TSHRALOX12KMT2A | |
| SCHEMBL2006154 | 0.91 | DRD2 (0.37) | MAPTCYP3A4MEN1KMT2ASRPK1 | |
| SCHEMBL2000833 | 0.91 | KMT2A (0.42) | MAPTCYP3A4TSHRMEN1BLM | |
| SCHEMBL2004983 | 0.90 | PTGES2 (0.42) | HSD17B10PPARGMAPTCYP3A4TSHR | |
| SCHEMBL2007194 | 0.90 | ALOX5AP (0.42) | ALOX5ALOX5APSTAT3S1PR1 | |
| SCHEMBL2004742 | 0.88 | STAT3 (0.35) | HSD17B10PPARGMAPTCYP3A4TSHR | |
| SCHEMBL2003864 | 0.88 | MAPT (0.38) | HSD17B10PPARGMAPTCYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |