Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12066159 | 1.00 | ACHE (0.35) | ACHEMAOBGRIA4SLC6A2SLC6A4 | |
| SCHEMBL18215079 | 1.00 | ACHE (0.35) | ACHEMAOBGRIA4SLC6A2SLC6A4 | |
| SCHEMBL15448667 | 0.88 | SLC6A2 (0.38) | ACHEMAOBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15448372 | 0.88 | SLC6A2 (0.38) | ACHEMAOBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20039938 | 0.83 | SLC6A2 (0.49) | ACHEGRIA4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20039943 | 0.83 | SLC6A2 (0.49) | ACHEGRIA4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20039942 | 0.82 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20039937 | 0.82 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17690421 | 0.82 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17150940 | 0.82 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3091012-B1 | CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF | CENTREXION THERAPEUTICS CORP (US) | 2018-04-11 | — | — | EP | disclosed |