Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579800 | 0.74 | CYP1A2 (0.54) | MAPTKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL17802125 | 0.71 | MAPT (0.46) | AKR1B1AKR1B10MAPTAKR1A1BACE1 | |
| SCHEMBL11926956 | 0.71 | BACE1 (0.42) | AKR1B1AKR1B10MAPTAKR1A1BACE1 | |
| SCHEMBL15542586 | 0.71 | MAPT (0.44) | BRAFKDRAKR1B1AKR1B10MAPT | |
| SCHEMBL16907583 | 0.71 | ALDH1A1 (0.59) | BRAFKDRMAPTKDM4EMEN1 | |
| SCHEMBL15541888 | 0.69 | RAB9A (0.41) | AKR1B1MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL30134236 | 0.69 | KDM4E (0.53) | BRAFKDRAKR1B1MAPTCYP26A1 | |
| SCHEMBL20939584 | 0.68 | DYRK1A (0.47) | MAPTKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL28332239 | 0.68 | KCNH2 (0.38) | MAPTKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL12533417 | 0.68 | PDK2 (0.37) | BRAFKDRAKR1B1AKR1B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864289-B1 | CYCLOPROPANECARBOXAMIDO-SUBSTITUTED AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS | CB THERAPEUTICS INC (KY) | 2018-04-11 | — | — | EP | disclosed |