Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 3/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20041048 | 0.87 | ALDH1A1 (0.51) | GAAALDH1A1HTTTDP1L3MBTL1 | |
| SCHEMBL20041020 | 0.84 | RAF1 (0.39) | GAARAF1SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL20040913 | 0.81 | LTA4H (0.46) | LTA4HTSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL28203624 | 0.81 | GAA (0.47) | GAALTA4HRAF1DHODHTSHR | |
| SCHEMBL16792531 | 0.81 | GAA (0.47) | GAALTA4HRAF1DHODHTSHR | |
| SCHEMBL30073041 | 0.81 | GAA (0.47) | GAALTA4HRAF1DHODHTSHR | |
| SCHEMBL20041006 | 0.80 | RAB9A (0.46) | GAASMN1; SMN2ALDH1A1HTTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL2868615 | 0.79 | GAA (0.46) | GAALTA4HRAF1DHODHTSHR | |
| SCHEMBL21295538 | 0.78 | RAF1 (0.58) | RAF1DHODHSMN1; SMN2HPGDCYP1A2 | |
| SCHEMBL20041087 | 0.76 | RAF1 (0.44) | RAF1SMN1; SMN2ALDH1A1HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080099-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2018-04-11 | — | — | EP | disclosed |