Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | STAT5B | P51692 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20041728 | 0.77 | MAOA (0.51) | MAOAMAOBSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1467625 | 0.75 | MAOA (0.54) | MAOAMAOBSMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL18394876 | 0.71 | MAOA (0.56) | MAOAMAOBSMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL29664470 | 0.71 | MAOA (0.56) | MAOAMAOBSMN1; SMN2HDAC3HDAC1 | |
| SCHEMBL2635637 | 0.71 | MAOA (0.70) | MAOAMAOBSMN1; SMN2CSNK2A1HDAC3 | |
| SCHEMBL3332845 | 0.70 | SORT1 (0.48) | MAOAMAOBSMN1; SMN2CSNK2A1HDAC3 | |
| SCHEMBL8690909 | 0.69 | MAOA (0.50) | MAOAMAOBSMN1; SMN2CSNK2A1HDAC3 | |
| SCHEMBL2825966 | 0.69 | SMN1; SMN2 (0.49) | MAOAMAOBSMN1; SMN2CSNK2A1RAB9A | |
| SCHEMBL243740 | 0.69 | SMN1; SMN2 (0.76) | SMN1; SMN2RAB9ANPC1POLBKMT2A | |
| SCHEMBL30602600 | 0.69 | SMN1; SMN2 (0.76) | SMN1; SMN2RAB9ANPC1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523297-B1 | NOVEL FURAZAN-3-CARBOXYLIC ACID DERIVATIVES AND USE THEREOF IN TREATMENT OF CANCER | UNIV BERLIN FREIE (DE) | 2021-07-07 | — | — | EP | disclosed |
| US-10683286-B2 | Furazan-3-carboxylic acid derivatives and use thereof in treatment of cancer | FREIE UNIVERSITAET BERLIN (DE) | 2020-06-16 | — | — | US | disclosed |
| WO-2018065536-A1 | NOVEL FURAZAN-3-CARBOXYLIC ACID DERIVATIVES AND USE THEREOF IN TREATMENT OF CANCER | FREIE UNIVERSITÄT BERLIN (DE) | 2018-04-12 | — | — | WO | disclosed |
| EP-3305783-A1 | NOVEL FURAZAN-3-CARBOXYLIC ACID DERIVATIVES AND USE THEREOF IN TREATMENT OF CANCER | Freie Universität Berlin (DE) | 2018-04-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10683286-B2 | Furazan-3-carboxylic acid derivatives and use thereof in treatment of cancer | FLT3, MCL1, MYD88 | MAOA 2761/4885MAOB 3039/4885SMN1; SMN2 3053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.