Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19559451 | 1.00 | TSHR (0.43) | TSHRADRA1APDE4AKMT2AMEN1 | |
| SCHEMBL19559581 | 0.84 | TSHR (0.43) | TSHRADRA1APDE4AKMT2AMEN1 | |
| SCHEMBL19559484 | 0.82 | TSHR (0.40) | TSHRADRA1APDE4AKMT2AMEN1 | |
| SCHEMBL16785342 | 0.82 | TSHR (0.40) | TSHRADRA1APDE4AKMT2AMEN1 | |
| SCHEMBL20041973 | 0.81 | TSHR (0.39) | TSHRADRA1APDE4AKMT2AMEN1 | |
| SCHEMBL19559443 | 0.81 | TSHR (0.37) | TSHRADRA1APDE4AKMT2AMEN1 | |
| SCHEMBL18117718 | 0.77 | MTNR1A (0.43) | KDM1A | |
| SCHEMBL18117753 | 0.76 | TSHR (0.69) | TSHRPDE4AKMT2AALDH1A1PDE4B | |
| SCHEMBL1268717 | 0.76 | TSHR (0.69) | TSHRPDE4AKMT2AALDH1A1PDE4B | |
| SCHEMBL18117758 | 0.75 | FPR1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305763-A1 | DEUTERATED OR ISOTOPICALLY LABELED UREA DERIVATIVES OR PHARMACOLOGICALLY ACCEPTABLE SALTS THEREOF USEFUL AS FPRL-1 AGONISTS | Kyorin Pharmaceutical Co., Ltd. (JP) | 2018-04-11 | — | — | EP | disclosed |