Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 3/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.38 |
| ▸ | PDE8B | O95263 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042678 | 0.84 | DDB1 (0.39) | DDB1CRBNPDE8BHPGDPARP1 | |
| SCHEMBL2810029 | 0.81 | MEN1 (0.36) | DDB1CRBNHPGDPDE10APARP1 | |
| SCHEMBL20042761 | 0.81 | MTOR (0.44) | DDB1CRBNPDE8BHPGDPDE10A | |
| SCHEMBL31246439 | 0.79 | PARP1 (0.41) | DDB1CRBNPDE10APARP1TNKS2 | |
| SCHEMBL16033726 | 0.75 | PARP1 (0.44) | DDB1CRBNPARP1TNKS2PARP2 | |
| SCHEMBL2806666 | 0.75 | MKNK1 (0.46) | DDB1CRBNPDE10APARP1TNKS2 | |
| SCHEMBL20042974 | 0.75 | MTOR (0.49) | PDE10AMTORGPR119 | |
| SCHEMBL29899535 | 0.74 | PARP1 (0.43) | DDB1CRBNPARP1TNKS2PARP2 | |
| SCHEMBL1262069 | 0.74 | DPP4 (0.45) | DDB1CRBNPARP1TNKS2PARP2 | |
| SCHEMBL22344925 | 0.74 | GPR119 (0.35) | DDB1CRBNHPGDPDE10AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |