Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.42 |
| ▸ | PDE4A | P27815 | 6/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | PDE8B | O95263 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042974 | 0.93 | MTOR (0.49) | MTORCHRM3PDE4APDE4BPDE4C | |
| SCHEMBL20042972 | 0.83 | MTOR (0.47) | MTORPDE10AGPR119CKS1BSKP1 | |
| SCHEMBL31614795 | 0.83 | MTOR (0.47) | MTORPDE10AGPR119CKS1BSKP1 | |
| SCHEMBL20042670 | 0.83 | MTOR (0.47) | MTORPDE10AGPR119CKS1BSKP1 | |
| SCHEMBL31516224 | 0.82 | MTOR (0.46) | MTORPDE10AGPR119CKS1BSKP1 | |
| SCHEMBL20042815 | 0.82 | MTOR (0.46) | MTORPDE10AGPR119CKS1BSKP1 | |
| SCHEMBL20042678 | 0.82 | DDB1 (0.39) | MTORGPR119PDE8BDDB1CRBN | |
| SCHEMBL20042708 | 0.81 | MTOR (0.46) | MTORPDE10AGPR119CKS1BSKP1 | |
| SCHEMBL20042676 | 0.81 | DDB1 (0.38) | MTORPDE10AGPR119PDE8BDDB1 | |
| SCHEMBL20042818 | 0.81 | MTOR (0.46) | MTORPDE10AGPR119CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |