Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PDE8B | O95263 | 1/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042676 | 0.84 | DDB1 (0.38) | DDB1CRBNPARP1TNKS2PARP2 | |
| SCHEMBL20042761 | 0.82 | MTOR (0.44) | DDB1CRBNGPR119MTORPDE8B | |
| SCHEMBL34470947 | 0.82 | MTOR (0.43) | PARP1TNKS2PARP2MAPTMTOR | |
| SCHEMBL31016562 | 0.81 | C5AR1 (0.39) | DDB1CRBNPARP1TNKS2PARP2 | |
| SCHEMBL20042662 | 0.81 | C5AR1 (0.39) | DDB1CRBNPARP1TNKS2PARP2 | |
| SCHEMBL31016608 | 0.79 | PARP1 (0.37) | DDB1CRBNPARP1TNKS2PARP2 | |
| SCHEMBL28653892 | 0.78 | PARP1 (0.44) | PARP1GPR119NAMPT | |
| SCHEMBL16033726 | 0.78 | PARP1 (0.44) | DDB1CRBNPARP1TNKS2PARP2 | |
| SCHEMBL31615021 | 0.78 | MTOR (0.40) | DDB1CRBNPARP1TNKS2PARP2 | |
| SCHEMBL20042758 | 0.78 | MTOR (0.40) | DDB1CRBNPARP1TNKS2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |