SCHEMBL20042979

SCHEMBL20042979

O=C(C1CCC1)N1Cc2nc(C3CCOCC3)nc(N3CCC3)c2C1

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.42
CNR2 P34972 5/20 0.38
IDH1 O75874 1/20 0.37
CHRM3 P20309 8/20 0.36
PDE4A P27815 6/20 0.36
PDE4B Q07343 6/20 0.36
PDE4C Q08493 6/20 0.36
PDE4D Q08499 6/20 0.36
PDE10A Q9Y233 2/20 0.34
MTOR P42345 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20042706 0.82 ALDH1A1 (0.43) ALDH1A1CNR2MTOR
SCHEMBL20042974 0.81 MTOR (0.49) CHRM3PDE4APDE4BPDE4CPDE4D
SCHEMBL20042799 0.79 ALDH1A1 (0.36) ALDH1A1CNR2IDH1
SCHEMBL20042800 0.79 CNR1 (0.45) ALDH1A1MTOR
SCHEMBL20042924 0.77 CNR2 (0.58) CNR2PDE4BMTOR
SCHEMBL20042806 0.76 CNR1 (0.47) ALDH1A1
SCHEMBL20042764 0.75 CNR1 (0.49) ALDH1A1
SCHEMBL20042718 0.75 CNR2 (0.40) ALDH1A1CNR2MTOR
SCHEMBL20042761 0.72 MTOR (0.44) CHRM3PDE4APDE4BPDE4CPDE4D
SCHEMBL20042816 0.71 CNR1 (0.45) ALDH1A1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018066718-A1 THERAPEUTIC COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-04-12 WO disclosed