SCHEMBL20043857

SCHEMBL20043857

Cc1ccc([C@H]2CN(C)C(=O)[C@@H]2C(=O)Nc2cccc(F)c2C)cc1C

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.37
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
MAPT P10636 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
CXCR2 P25025 4/20 0.35
EPHX2 P34913 1/20 0.35
ALDH1A1 P00352 2/20 0.34
GAA P10253 1/20 0.34
LMNA P02545 2/20 0.34
RAB9A P51151 1/20 0.34
HTT P42858 1/20 0.34
ABL1 P00519 1/20 0.33
RIN1 Q13671 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20044394 0.94 THRB (0.39) THRBSMN1; SMN2KMT2AMEN1MAPT
SCHEMBL20044088 0.94 THRB (0.39) THRBSMN1; SMN2KMT2AMEN1MAPT
SCHEMBL20044144 0.92 TP53 (0.39) SMN1; SMN2KMT2AMEN1MAPTL3MBTL1
SCHEMBL20044142 0.92 KMT2A (0.44) SMN1; SMN2KMT2AMEN1MAPTL3MBTL1
SCHEMBL20044123 0.91 THRB (0.41) THRBSMN1; SMN2MAPTCXCR2EPHX2
SCHEMBL20044297 0.90 LMNA (0.39) THRBSMN1; SMN2KMT2AMEN1MAPT
SCHEMBL20048593 0.89 THRB (0.40) THRBSMN1; SMN2KMT2AMEN1MAPT
SCHEMBL20044320 0.89 THRB (0.48) THRBSMN1; SMN2KMT2AMEN1MAPT
SCHEMBL20048568 0.89 THRB (0.41) THRBSMN1; SMN2KMT2AMEN1MAPT
SCHEMBL24310398 0.88 THRB (0.42) THRBSMN1; SMN2KMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 THRB 2171/4885SMN1; SMN2 4288/4885KMT2A 1699/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 THRB 2171/4885SMN1; SMN2 4288/4885KMT2A 1699/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 THRB 2171/4885SMN1; SMN2 4288/4885KMT2A 1699/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 THRB 2193/4885SMN1; SMN2 4295/4885KMT2A 1693/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 THRB 2171/4885SMN1; SMN2 4288/4885KMT2A 1699/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 THRB 2171/4885SMN1; SMN2 4288/4885KMT2A 1699/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 THRB 2171/4885SMN1; SMN2 4288/4885KMT2A 1699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.