SCHEMBL20043882

SCHEMBL20043882

COc1cc([C@H]2CN(C)C(=O)[C@@H]2C(=O)Nc2ccccc2F)ccc1C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
MAPT P10636 1/20 0.39
SMN1; SMN2 Q16637 3/20 0.38
KDM4E B2RXH2 2/20 0.37
LMNA P02545 2/20 0.37
USP2 O75604 1/20 0.37
PDE4D Q08499 1/20 0.37
TP53 P04637 1/20 0.37
RAB9A P51151 2/20 0.37
GAA P10253 1/20 0.37
CACNA1S Q13698 1/20 0.37
HTR1D P28221 1/20 0.36
HTR1B P28222 1/20 0.36
NPC1 O15118 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20043884 0.93 HTR1D (0.41) ALDH1A1TP53CACNA1SHTR1DHTR1B
SCHEMBL20044094 0.93 ALDH1A1 (0.41) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL20043883 0.90 MEN1 (0.41) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL20043951 0.90 ALDH1A1 (0.46) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL20044360 0.90 KMT2A (0.42) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL20044128 0.88 SLC6A2 (0.43) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL20044462 0.87 SMN1; SMN2 (0.44) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL20044304 0.86 SMN1; SMN2 (0.48) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL20044097 0.86 HTR1D (0.39) ALDH1A1PDE4DTP53CACNA1SHTR1D
SCHEMBL20044498 0.85 MEN1 (0.38) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MEN1 3340/4885KMT2A 1699/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MEN1 3340/4885KMT2A 1699/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MEN1 3340/4885KMT2A 1699/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1182/4885MEN1 3362/4885KMT2A 1693/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MEN1 3340/4885KMT2A 1699/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MEN1 3340/4885KMT2A 1699/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885MEN1 3340/4885KMT2A 1699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.