SCHEMBL20043883

SCHEMBL20043883

COc1cc([C@H]2CN(C)C(=O)[C@@H]2C(=O)Nc2ccccc2SC)ccc1C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
POLB P06746 1/20 0.40
MAPT P10636 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
TSHR P16473 2/20 0.39
ALDH1A1 P00352 5/20 0.39
RAB9A P51151 1/20 0.39
HSD17B10 Q99714 3/20 0.37
LMNA P02545 1/20 0.36
DDB1 Q16531 1/20 0.35
CRBN Q96SW2 1/20 0.35
KDM4E B2RXH2 1/20 0.35
HPGD P15428 1/20 0.35
PDE4D Q08499 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20044098 0.93 ALDH1A1 (0.41) MEN1KMT2APOLBMAPTSMN1; SMN2
SCHEMBL20043882 0.90 ALDH1A1 (0.39) MEN1KMT2AMAPTSMN1; SMN2ALDH1A1
SCHEMBL20043954 0.89 KMT2A (0.50) MEN1KMT2APOLBMAPTSMN1; SMN2
SCHEMBL20044377 0.88 KMT2A (0.43) MEN1KMT2APOLBMAPTSMN1; SMN2
SCHEMBL20043884 0.87 HTR1D (0.41) TSHRALDH1A1
SCHEMBL20044129 0.86 ALDH1A1 (0.43) MEN1KMT2APOLBMAPTSMN1; SMN2
SCHEMBL20044305 0.85 MEN1 (0.45) MEN1KMT2APOLBMAPTSMN1; SMN2
SCHEMBL20044438 0.83 HSD17B10 (0.42) MEN1KMT2AMAPTSMN1; SMN2ALDH1A1
SCHEMBL20044094 0.83 ALDH1A1 (0.41) MEN1KMT2AMAPTSMN1; SMN2ALDH1A1
SCHEMBL20048479 0.82 ALDH1A1 (0.46) MEN1KMT2AMAPTALDH1A1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885POLB 3194/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885POLB 3194/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885POLB 3194/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 MEN1 3362/4885KMT2A 1693/4885POLB 3164/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885POLB 3194/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885POLB 3194/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885POLB 3194/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.