SCHEMBL20043955

SCHEMBL20043955

COc1cc([C@H]2CN(C)C(=O)[C@@H]2C(=O)Nc2ccccc2F)cc(C(F)(F)F)c1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.41
FPR2 P25090 1/20 0.41
USP2 O75604 1/20 0.41
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
MAPT P10636 1/20 0.39
RAB9A P51151 4/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
NPSR1 Q6W5P4 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
NPC1 O15118 1/20 0.38
PKM P14618 1/20 0.38
NFKB1 P19838 1/20 0.38
NFKB2 Q00653 1/20 0.38
RELA Q04206 1/20 0.38
P2RY1 P47900 1/20 0.36
LMNA P02545 2/20 0.36
EPHX2 P34913 1/20 0.36
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20043960 0.93 ALDH1A1 (0.36) ALDH1A1FPR2USP2MEN1KMT2A
SCHEMBL20044089 0.92 FPR2 (0.45) ALDH1A1FPR2USP2MEN1KMT2A
SCHEMBL20043956 0.90 MEN1 (0.41) ALDH1A1MEN1KMT2AMAPTRAB9A
SCHEMBL20044810 0.87 MEN1 (0.40) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL20044458 0.87 MEN1 (0.40) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL18129440 0.86 MEN1 (0.42) ALDH1A1MEN1KMT2AMAPTP2RY1
SCHEMBL22345899 0.86 MEN1 (0.42) ALDH1A1MEN1KMT2AMAPTP2RY1
SCHEMBL29936176 0.86 MEN1 (0.42) ALDH1A1MEN1KMT2AMAPTP2RY1
SCHEMBL29368016 0.86 MEN1 (0.42) ALDH1A1MEN1KMT2AMAPTP2RY1
SCHEMBL29581775 0.86 MEN1 (0.42) ALDH1A1MEN1KMT2AMAPTP2RY1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885FPR2 1728/4885USP2 2535/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885FPR2 1728/4885USP2 2535/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885FPR2 1728/4885USP2 2535/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1182/4885FPR2 1706/4885USP2 2623/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885FPR2 1728/4885USP2 2535/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885FPR2 1728/4885USP2 2535/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885FPR2 1728/4885USP2 2535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.