SCHEMBL20044003

SCHEMBL20044003

CN1C[C@H](c2cc(F)c(C(F)(F)F)c(F)c2)[C@@H](C(=O)Nc2ccccc2S(C)(=O)=O)C1=O

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 4/20 0.36
FPR1 P21462 3/20 0.36
F10 P00742 3/20 0.35
TSHR P16473 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
CNR2 P34972 1/20 0.35
TYK2 P29597 3/20 0.34
HCRTR1 O43613 1/20 0.34
EPHX2 P34913 1/20 0.34
JAK2 O60674 1/20 0.34
JAK1 P23458 1/20 0.34
ALDH1A1 P00352 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
MAPT P10636 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20043982 0.91 CA1 (0.39) FPR2FPR1F10TSHRSMN1; SMN2
SCHEMBL20044822 0.89 FPR2 (0.36) FPR2FPR1CNR2TYK2HCRTR1
SCHEMBL20044005 0.88 MEN1 (0.43) TSHRSMN1; SMN2MEN1KMT2AEPHX2
SCHEMBL20043861 0.88 CNR2 (0.38) F10TSHRSMN1; SMN2MEN1KMT2A
SCHEMBL20044501 0.86 FPR2 (0.39) FPR2FPR1CNR2HCRTR1L3MBTL1
SCHEMBL20044830 0.85 CNR2 (0.36) FPR2FPR1CNR2TYK2HCRTR1
SCHEMBL20044825 0.85 L3MBTL1 (0.39) FPR2FPR1TSHRSMN1; SMN2MEN1
SCHEMBL20044826 0.85 F10 (0.36) FPR2FPR1F10MEN1KMT2A
SCHEMBL20044002 0.85 TP53 (0.38) TSHRSMN1; SMN2MEN1KMT2AEPHX2
SCHEMBL20044763 0.84 CNR2 (0.40) F10KMT2ACNR2TYK2HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 FPR2 1728/4885FPR1 1301/4885F10 3703/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 FPR2 1728/4885FPR1 1301/4885F10 3703/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 FPR2 1728/4885FPR1 1301/4885F10 3703/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 FPR2 1706/4885FPR1 1276/4885F10 3694/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 FPR2 1728/4885FPR1 1301/4885F10 3703/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 FPR2 1728/4885FPR1 1301/4885F10 3703/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 FPR2 1728/4885FPR1 1301/4885F10 3703/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.