SCHEMBL20044009

SCHEMBL20044009

CCOc1ccc([C@H]2CN(C)C(=O)[C@@H]2C(=O)Nc2ccc(F)cc2F)cc1

nearest known ligand 0.58

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
POLB P06746 2/20 0.51
ALDH1A1 P00352 1/20 0.42
HRH3 Q9Y5N1 5/20 0.41
TP53 P04637 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
HTR2A P28223 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20044071 0.90 ATM (0.51) ATML3MBTL1POLBTP53SMN1; SMN2
SCHEMBL20044010 0.88 L3MBTL1 (0.44) ATML3MBTL1ALDH1A1TP53SMN1; SMN2
SCHEMBL20044063 0.86 POLB (0.45) ATML3MBTL1POLBALDH1A1TP53
SCHEMBL20044008 0.85 ATM (0.41) ATML3MBTL1POLBALDH1A1TP53
SCHEMBL21662058 0.84 TP53 (0.45) ATML3MBTL1POLBTP53SMN1; SMN2
SCHEMBL20044868 0.83 CYP1A2 (0.43) ATML3MBTL1TP53SMN1; SMN2
SCHEMBL20044013 0.82 ATM (0.55) ATML3MBTL1POLBALDH1A1HRH3
SCHEMBL20044138 0.80 NR4A2 (0.43) ATML3MBTL1POLBALDH1A1TP53
SCHEMBL20044062 0.80 SMN1; SMN2 (0.45) ATML3MBTL1ALDH1A1TP53SMN1; SMN2
SCHEMBL20044203 0.80 GAA (0.41) ATML3MBTL1POLBTP53SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ATM 1879/4885L3MBTL1 2969/4885POLB 3194/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ATM 1879/4885L3MBTL1 2969/4885POLB 3194/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ATM 1879/4885L3MBTL1 2969/4885POLB 3194/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ATM 1875/4885L3MBTL1 3033/4885POLB 3164/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ATM 1879/4885L3MBTL1 2969/4885POLB 3194/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ATM 1879/4885L3MBTL1 2969/4885POLB 3194/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ATM 1879/4885L3MBTL1 2969/4885POLB 3194/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.