SCHEMBL20044091

SCHEMBL20044091

COc1cc(OC)cc([C@H]2CN(C)C(=O)[C@@H]2C(=O)Nc2ccccc2SC)c1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 7/20 0.47
KMT2A Q03164 7/20 0.47
HSD17B10 Q99714 2/20 0.45
MAPT P10636 4/20 0.44
LMNA P02545 2/20 0.44
RAB9A P51151 3/20 0.44
NPC1 O15118 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
PKM P14618 1/20 0.44
ALDH1A1 P00352 4/20 0.43
POLB P06746 1/20 0.41
MAPK1 P28482 1/20 0.41
TSHR P16473 1/20 0.40
KDM4E B2RXH2 1/20 0.39
HCRTR1 O43613 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20043956 0.91 MEN1 (0.41) MEN1KMT2AHSD17B10MAPTLMNA
SCHEMBL20044305 0.88 MEN1 (0.45) MEN1KMT2AHSD17B10MAPTLMNA
SCHEMBL20044089 0.88 FPR2 (0.45) MEN1KMT2AMAPTLMNARAB9A
SCHEMBL20043911 0.86 HSD17B10 (0.45) MEN1KMT2AHSD17B10MAPTLMNA
SCHEMBL20043954 0.86 KMT2A (0.50) MEN1KMT2AHSD17B10MAPTLMNA
SCHEMBL20043860 0.85 HSD17B10 (0.44) MEN1KMT2AHSD17B10MAPTLMNA
SCHEMBL20043966 0.84 HSD17B10 (0.43) MEN1KMT2AHSD17B10MAPTLMNA
SCHEMBL20044133 0.84 HSD17B10 (0.43) MEN1KMT2AHSD17B10MAPTLMNA
SCHEMBL20044303 0.84 KMT2A (0.56) MEN1KMT2AMAPTLMNARAB9A
SCHEMBL20044426 0.84 ALDH1A1 (0.40) MEN1KMT2AHSD17B10MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885HSD17B10 1966/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885HSD17B10 1966/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885HSD17B10 1966/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 MEN1 3362/4885KMT2A 1693/4885HSD17B10 1933/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885HSD17B10 1966/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885HSD17B10 1966/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 MEN1 3340/4885KMT2A 1699/4885HSD17B10 1966/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.