SCHEMBL20044129

SCHEMBL20044129

COc1ccc([C@H]2CN(C)C(=O)[C@@H]2C(=O)Nc2ccccc2SC)cc1F

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.43
KMT2A Q03164 4/20 0.43
MEN1 O00255 3/20 0.43
MAPT P10636 2/20 0.43
RAB9A P51151 1/20 0.43
POLB P06746 1/20 0.42
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
TSHR P16473 2/20 0.41
FPR1 P21462 1/20 0.39
FPR2 P25090 1/20 0.39
HSD17B10 Q99714 3/20 0.39
KDM1A O60341 2/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
HPGD P15428 1/20 0.38
F10 P00742 1/20 0.37
LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20044377 0.93 KMT2A (0.43) ALDH1A1KMT2AMEN1MAPTRAB9A
SCHEMBL20044128 0.91 SLC6A2 (0.43) ALDH1A1KMT2AMEN1MAPTRAB9A
SCHEMBL20043954 0.91 KMT2A (0.50) ALDH1A1KMT2AMEN1MAPTRAB9A
SCHEMBL20044098 0.88 ALDH1A1 (0.41) ALDH1A1KMT2AMEN1MAPTRAB9A
SCHEMBL20044127 0.88 SLC6A2 (0.42) ALDH1A1KMT2AMEN1SLC6A2SLC6A4
SCHEMBL20044090 0.87 HSD17B10 (0.41) ALDH1A1KMT2AMEN1MAPTRAB9A
SCHEMBL20043883 0.86 MEN1 (0.41) ALDH1A1KMT2AMEN1MAPTRAB9A
SCHEMBL20043966 0.86 HSD17B10 (0.43) ALDH1A1KMT2AMEN1MAPTRAB9A
SCHEMBL22621465 0.86 SLC6A2 (0.41) MAPTSLC6A2SLC6A4SLC6A3TSHR
SCHEMBL20044410 0.85 HSD17B10 (0.41) ALDH1A1KMT2AMEN1MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885KMT2A 1699/4885MEN1 3340/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885KMT2A 1699/4885MEN1 3340/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885KMT2A 1699/4885MEN1 3340/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1182/4885KMT2A 1693/4885MEN1 3362/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885KMT2A 1699/4885MEN1 3340/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALDH1A1 1202/4885KMT2A 1699/4885MEN1 3340/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALDH1A1 1202/4885KMT2A 1699/4885MEN1 3340/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.