SCHEMBL20044726

SCHEMBL20044726

COc1ccc(C2CN(C)C(=O)C2C(=O)Nc2cccc(F)c2F)cc1OC(C)C

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.38
TSHR P16473 1/20 0.38
HSD17B10 Q99714 3/20 0.37
MAPT P10636 1/20 0.37
BRPF1 P55201 2/20 0.36
PDE4B Q07343 6/20 0.36
PDE4D Q08499 4/20 0.36
PDE4A P27815 3/20 0.36
PDE4C Q08493 3/20 0.36
LMNA P02545 1/20 0.36
SLC6A2 P23975 2/20 0.35
SLC6A4 P31645 2/20 0.35
SLC6A3 Q01959 2/20 0.35
EED O75530 1/20 0.34
TP53 P04637 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20043953 0.93 PDE4B (0.42) ALOX15TSHRHSD17B10PDE4BPDE4D
SCHEMBL20044178 0.92 TP53 (0.35) MAPTBRPF1TP53ALDH1A1
SCHEMBL20044127 0.89 SLC6A2 (0.42) ALOX15TSHRPDE4BPDE4DPDE4A
SCHEMBL20044407 0.89 TP53 (0.37) ALOX15TSHRMAPTPDE4BPDE4D
SCHEMBL20044757 0.88 MAPT (0.39) ALOX15TSHRMAPTPDE4BPDE4D
SCHEMBL20044725 0.88 ALOX15 (0.36) ALOX15TSHRHSD17B10LMNASLC6A2
SCHEMBL20044756 0.88 ALOX15 (0.36) ALOX15TSHRHSD17B10MAPTPDE4B
SCHEMBL20044749 0.87 TP53 (0.38) ALOX15TSHRMAPTLMNATP53
SCHEMBL20044516 0.87 KMT2A (0.40) TSHRLMNATP53KDM4EALDH1A1
SCHEMBL22621490 0.87 NPC1 (0.36) TSHRMAPTLMNATP53ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALOX15 3189/4885TSHR 1106/4885HSD17B10 1966/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALOX15 3189/4885TSHR 1106/4885HSD17B10 1966/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALOX15 3189/4885TSHR 1106/4885HSD17B10 1966/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALOX15 3176/4885TSHR 1114/4885HSD17B10 1933/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALOX15 3189/4885TSHR 1106/4885HSD17B10 1966/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ALOX15 3189/4885TSHR 1106/4885HSD17B10 1966/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ALOX15 3189/4885TSHR 1106/4885HSD17B10 1966/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.