SCHEMBL20044729

SCHEMBL20044729

CCOc1cc(C)cc(C2CN(C)C(=O)C2C(=O)Nc2cccc(F)c2F)c1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 4/20 0.40
SMN1; SMN2 Q16637 3/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
ATM Q13315 1/20 0.37
TP53 P04637 2/20 0.36
RAB9A P51151 4/20 0.36
MAPT P10636 2/20 0.35
ALDH1A1 P00352 2/20 0.35
KDM4E B2RXH2 1/20 0.35
HPGD P15428 1/20 0.35
HTT P42858 1/20 0.35
NPC1 O15118 3/20 0.33
PKM P14618 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
CHRM3 P20309 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20044738 0.92 ATM (0.39) KAT6ASMN1; SMN2L3MBTL1ATMTP53
SCHEMBL20044064 0.90 SMN1; SMN2 (0.44) SMN1; SMN2L3MBTL1ATMTP53RAB9A
SCHEMBL20044889 0.90 ALDH1A1 (0.38) SMN1; SMN2TP53RAB9AMAPTALDH1A1
SCHEMBL20044084 0.89 SMN1; SMN2 (0.37) SMN1; SMN2L3MBTL1ATMTP53MAPT
SCHEMBL20044733 0.89 SMN1; SMN2 (0.37) SMN1; SMN2L3MBTL1ATMTP53MAPT
SCHEMBL20044016 0.89 TP53 (0.40) SMN1; SMN2TP53MAPTALDH1A1KDM4E
SCHEMBL20044008 0.88 ATM (0.41) SMN1; SMN2L3MBTL1ATMTP53MAPT
SCHEMBL20043948 0.86 TP53 (0.38) SMN1; SMN2TP53MAPTALDH1A1KDM4E
SCHEMBL25893566 0.86 TP53 (0.38) SMN1; SMN2TP53MAPTALDH1A1KDM4E
SCHEMBL20044899 0.84 TP53 (0.37) SMN1; SMN2TP53MAPTALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 KAT6A 3476/4885SMN1; SMN2 4288/4885L3MBTL1 2969/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 KAT6A 3476/4885SMN1; SMN2 4288/4885L3MBTL1 2969/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 KAT6A 3476/4885SMN1; SMN2 4288/4885L3MBTL1 2969/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 KAT6A 3469/4885SMN1; SMN2 4295/4885L3MBTL1 3033/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 KAT6A 3476/4885SMN1; SMN2 4288/4885L3MBTL1 2969/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 KAT6A 3476/4885SMN1; SMN2 4288/4885L3MBTL1 2969/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 KAT6A 3476/4885SMN1; SMN2 4288/4885L3MBTL1 2969/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.