SCHEMBL20044738

SCHEMBL20044738

CCOc1cc(F)cc(C2CN(C)C(=O)C2C(=O)Nc2cccc(F)c2F)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TP53 P04637 3/20 0.37
KAT6A Q92794 2/20 0.35
MAPT P10636 5/20 0.34
LMNA P02545 1/20 0.34
ALDH1A1 P00352 2/20 0.34
FPR2 P25090 1/20 0.34
KDM4E B2RXH2 1/20 0.34
HPGD P15428 1/20 0.34
HTT P42858 1/20 0.34
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
TSHR P16473 1/20 0.34
CHRM3 P20309 1/20 0.33
SLC5A1 P13866 1/20 0.33
POLB P06746 1/20 0.33
UBE2M P61081 1/20 0.32
DCUN1D1 Q96GG9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20044729 0.92 KAT6A (0.40) ATML3MBTL1SMN1; SMN2TP53KAT6A
SCHEMBL20044064 0.91 SMN1; SMN2 (0.44) ATML3MBTL1SMN1; SMN2TP53MAPT
SCHEMBL20044734 0.91 TP53 (0.35) SMN1; SMN2TP53MAPTLMNAALDH1A1
SCHEMBL20044735 0.90 ALDH1A1 (0.38) SMN1; SMN2TP53MAPTALDH1A1FPR2
SCHEMBL20044084 0.90 SMN1; SMN2 (0.37) ATML3MBTL1SMN1; SMN2TP53MAPT
SCHEMBL20044733 0.90 SMN1; SMN2 (0.37) ATML3MBTL1SMN1; SMN2TP53MAPT
SCHEMBL20044008 0.89 ATM (0.41) ATML3MBTL1SMN1; SMN2TP53MAPT
SCHEMBL22986865 0.89 TP53 (0.40) SMN1; SMN2TP53MAPTLMNAALDH1A1
SCHEMBL22621472 0.89 TP53 (0.40) SMN1; SMN2TP53MAPTLMNAALDH1A1
SCHEMBL20044761 0.88 TP53 (0.35) SMN1; SMN2TP53KAT6AMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ATM 1879/4885L3MBTL1 2969/4885SMN1; SMN2 4288/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ATM 1879/4885L3MBTL1 2969/4885SMN1; SMN2 4288/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ATM 1879/4885L3MBTL1 2969/4885SMN1; SMN2 4288/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ATM 1875/4885L3MBTL1 3033/4885SMN1; SMN2 4295/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ATM 1879/4885L3MBTL1 2969/4885SMN1; SMN2 4288/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 ATM 1879/4885L3MBTL1 2969/4885SMN1; SMN2 4288/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 ATM 1879/4885L3MBTL1 2969/4885SMN1; SMN2 4288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.