SCHEMBL20044740

SCHEMBL20044740

CN1CC(c2cc(F)c(Cl)c(F)c2)C(C(=O)Nc2cccc(F)c2F)C1=O

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.39
MEN1 O00255 1/20 0.36
MAPT P10636 1/20 0.36
KMT2A Q03164 1/20 0.36
P2RX7 Q99572 3/20 0.36
CHRM3 P20309 2/20 0.35
CXCR2 P25025 7/20 0.35
ALDH1A1 P00352 2/20 0.34
LMNA P02545 1/20 0.34
FPR1 P21462 1/20 0.33
FPR2 P25090 1/20 0.33
RIPK1 Q13546 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20043988 0.93 TP53 (0.41) TP53MEN1MAPTKMT2ACHRM3
SCHEMBL20044739 0.92 TP53 (0.38) TP53MEN1MAPTKMT2AP2RX7
SCHEMBL20044343 0.92 TP53 (0.39) TP53MEN1MAPTKMT2AP2RX7
SCHEMBL20044747 0.91 TP53 (0.40) TP53MEN1MAPTKMT2ACHRM3
SCHEMBL20044811 0.90 TP53 (0.40) TP53MEN1MAPTKMT2AP2RX7
SCHEMBL20044538 0.90 TP53 (0.40) TP53MEN1MAPTKMT2AP2RX7
SCHEMBL20044340 0.90 TP53 (0.38) TP53MEN1MAPTKMT2ACXCR2
SCHEMBL22986865 0.89 TP53 (0.40) TP53MEN1MAPTKMT2AP2RX7
SCHEMBL22621472 0.89 TP53 (0.40) TP53MEN1MAPTKMT2AP2RX7
SCHEMBL20044080 0.89 TP53 (0.37) TP53MEN1MAPTKMT2AP2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 TP53 1193/4885MEN1 3340/4885MAPT 3629/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 TP53 1193/4885MEN1 3340/4885MAPT 3629/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 TP53 1193/4885MEN1 3340/4885MAPT 3629/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 TP53 1230/4885MEN1 3362/4885MAPT 3633/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 TP53 1193/4885MEN1 3340/4885MAPT 3629/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 TP53 1193/4885MEN1 3340/4885MAPT 3629/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 TP53 1193/4885MEN1 3340/4885MAPT 3629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.