SCHEMBL22986865

SCHEMBL22986865

CN1CC(c2cc(F)cc(F)c2)C(C(=O)Nc2cccc(F)c2F)C1=O

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.40
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
MAPT P10636 1/20 0.38
ALDH1A1 P00352 2/20 0.35
LMNA P02545 1/20 0.35
TRPV1 Q8NER1 2/20 0.35
CHRM3 P20309 1/20 0.34
P2RX7 Q99572 2/20 0.34
PLA2G7 Q13093 2/20 0.33
KDM4E B2RXH2 1/20 0.33
TSHR P16473 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
UBE2M P61081 1/20 0.33
DCUN1D1 Q96GG9 1/20 0.33
NPY5R Q15761 1/20 0.33
THRB P10828 1/20 0.33
OPRK1 P41145 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22621472 1.00 TP53 (0.40) TP53MEN1KMT2AMAPTALDH1A1
SCHEMBL20043948 0.94 TP53 (0.38) TP53MEN1KMT2AMAPTALDH1A1
SCHEMBL25893566 0.94 TP53 (0.38) TP53MEN1KMT2AMAPTALDH1A1
SCHEMBL20044080 0.93 TP53 (0.37) TP53MEN1KMT2AMAPTALDH1A1
SCHEMBL20043988 0.92 TP53 (0.41) TP53MEN1KMT2AMAPTALDH1A1
SCHEMBL20044735 0.91 ALDH1A1 (0.38) TP53MEN1KMT2AMAPTALDH1A1
SCHEMBL20044301 0.91 TP53 (0.36) TP53MEN1KMT2AMAPTALDH1A1
SCHEMBL24310398 0.90 THRB (0.42) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL20044747 0.90 TP53 (0.40) TP53MEN1KMT2AMAPTALDH1A1
SCHEMBL20044016 0.90 TP53 (0.40) TP53MEN1KMT2AMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12162840-B2 Herbicidal compositions SYNGENTA CROP PROTECTION AG (CH) 2024-12-10 US claimed
EP-3890487-B1 HERBICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2024-06-12 EP claimed
EP-3923724-B1 HERBICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION AG (CH) 2023-07-26 EP claimed
US-20220125052-A1 Herbicidal Compositions SYNGENTA CROP PROTECTION AG (CH) 2022-04-28 US claimed
US-20220119353-A1 Herbicidal Compositions SYNGENTA PARTICIPATIONS AG (CH) 2022-04-21 US claimed
US-12162840-B2 Herbicidal compositions SYNGENTA CROP PROTECTION AG (CH) 2024-12-10 US disclosed
US-20230278972-A1 SUBSTITUTED HALOALKYL SULFONANILIDE HERBICIDES FMC CORPORATION 2023-09-07 US disclosed
US-20230278972-A1 SUBSTITUTED HALOALKYL SULFONANILIDE HERBICIDES FMC CORPORATION 2023-09-07 US disclosed
EP-3663282-B1 PYRROLIDINONE HERBICIDES FMC CORP (US) 2022-05-18 EP disclosed
US-20220125052-A1 Herbicidal Compositions SYNGENTA CROP PROTECTION AG (CH) 2022-04-28 US disclosed
US-20220125052-A1 Herbicidal Compositions SYNGENTA CROP PROTECTION AG (CH) 2022-04-28 US disclosed
US-20220119354-A1 DIAMINO-SUBSTITUTED PYRIDINES AND PYRIMIDINES AS HERBICIDES FMC CORP (US) 2022-04-21 US disclosed
US-20220119353-A1 Herbicidal Compositions SYNGENTA PARTICIPATIONS AG (CH) 2022-04-21 US disclosed
US-20220119353-A1 Herbicidal Compositions SYNGENTA PARTICIPATIONS AG (CH) 2022-04-21 US disclosed
US-20210045385-A1 PYRIDAZINONE-SUBSTITUTED KETOXIMES AS HERBICIDES FMC CORP (US) 2021-02-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210045385-A1 PYRIDAZINONE-SUBSTITUTED KETOXIMES AS HERBICIDES CYP1A2, CYP1B1, CYP1A1 TP53 2918/4885MEN1 4471/4885KMT2A 655/4885
US-20230278972-A1 SUBSTITUTED HALOALKYL SULFONANILIDE HERBICIDES CBR3, CBR1, GRHPR TP53 2842/4885MEN1 4873/4885KMT2A 3816/4885
US-12162840-B2 Herbicidal compositions DDT, HPD, PNPO TP53 4519/4885MEN1 4581/4885KMT2A 822/4885
US-20220119354-A1 DIAMINO-SUBSTITUTED PYRIDINES AND PYRIMIDINES AS HERBICIDES DDX41, AOC1, DPYD TP53 890/4885MEN1 4061/4885KMT2A 2696/4885
US-20220125052-A1 Herbicidal Compositions DDT, HPD, DHFR TP53 4324/4885MEN1 4524/4885KMT2A 443/4885
US-20220119353-A1 Herbicidal Compositions DDT, HPD, PNPO TP53 4519/4885MEN1 4581/4885KMT2A 822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.