Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyramide SCHEMBL27747519 | 0.88 | FBP1 (0.36) | ALDH1A1LMNACYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL10321979 | 0.85 | GPR35 (0.41) | ALDH1A1LMNACYP1A2CYP2C19ERN1 | |
| SCHEMBL29060291 | 0.83 | KDM4E (0.44) | ALDH1A1LMNACYP1A2CYP2C19ERN1 | |
| SCHEMBL28417466 | 0.81 | GSK3B (0.39) | ALDH1A1LMNACYP1A2CYP2C19ERN1 | |
| SCHEMBL29060088 | 0.81 | MAPT (0.42) | ALDH1A1LMNACYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL25186795 | 0.79 | CYP1A2 (0.38) | ALDH1A1LMNACYP1A2CYP2C19ERN1 | |
| SCHEMBL30418856 | 0.79 | CYP1A2 (0.38) | ALDH1A1LMNACYP1A2CYP2C19ERN1 | |
| SCHEMBL27986105 | 0.79 | TSHR (0.49) | ALDH1A1LMNAPARP1SMN1; SMN2CYP3A4 | |
| SCHEMBL15900437 | 0.76 | ALDH1A1 (0.46) | ALDH1A1CYP1A2CYP2C19SMN1; SMN2CYP3A4 | |
| SCHEMBL28736319 | 0.76 | MAPT (0.37) | ALDH1A1LMNACYP1A2CYP2C19ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115677689-B | Polysubstituted benzene PD-L1 inhibitor, composition and application thereof | 杭州和正医药有限公司 | 2024-10-22 | — | — | CN | disclosed |
| CN-115677689-A | Polysubstituted benzene PD-L1 inhibitor, composition and application thereof | 杭州和正医药有限公司 | 2023-02-03 | — | — | CN | disclosed |
| WO-2023006019-A1 | POLYSUBSTITUTED BENZENE PD-L1 INHIBITOR, COMPOSITION AND USE THEREOF | 杭州和正医药有限公司 | 2023-02-02 | — | — | WO | disclosed |
| US-7960394-B2 | 3,8-dimethyl-2-[4-(3-piperidin-1-ylpropoxy)phenyl]-4(3H)-quinazolinone; 6-chloro-3-methyl-2-[4-(3-piperidin-1-ylpropoxy)phenyl]pyrido[3,4-d]-pyrimidin-4(3H)-one; 2-[4-(1-cyclopentyl-4-piperidinyloxy)phenyl]-3-methylpyrido[2,3-d]-pyrimidin-4(3H)-one; treats metabolic, nervous system, vascular disorders | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2011-06-14 | — | — | US | disclosed |
| US-20080275069-A1 | Quinazoline Derivative | MSD K.K. (JP) | 2008-11-06 | — | — | US | disclosed |
| CN-1960977-A | Quinazoline derivative | BANYU PHARMA CO LTD (JP) | 2007-05-09 | — | — | CN | disclosed |
| EP-1757594-A1 | QUINAZOLINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-02-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275069-A1 | Quinazoline Derivative | HRH3, HRH4, HRH2 | ALDH1A1 2782/4885LMNA 4491/4885CYP1A2 1037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.