Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 18/20 | 0.72 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16944583 | 0.84 | OPRK1 (1.00) | OPRK1 | |
| SCHEMBL18994612 | 0.81 | OPRK1 (0.67) | OPRK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL20045330 | 0.79 | OPRK1 (0.46) | OPRK1 | |
| SCHEMBL20045301 | 0.76 | OPRK1 (0.77) | OPRK1 | |
| SCHEMBL20045306 | 0.76 | OPRK1 (0.77) | OPRK1 | |
| SCHEMBL24670690 | 0.70 | PDE10A (0.48) | OPRK1 | |
| SCHEMBL30066350 | 0.70 | PDE10A (0.48) | OPRK1 | |
| SCHEMBL20045344 | 0.69 | OPRK1 (0.73) | OPRK1 | |
| SCHEMBL21170914 | 0.69 | OPRK1 (0.51) | OPRK1 | |
| SCHEMBL20045325 | 0.68 | OPRK1 (0.73) | OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180099954-A1 | NOVEL KAPPA OPIOID LIGANDS | SCRIPPS RESEARCH INST (US) | 2018-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180099954-A1 | NOVEL KAPPA OPIOID LIGANDS | OPRK1, OPRD1, OPRL1 | OPRK1 1/4885JAK2 2529/4885JAK1 2791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.