Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20047170 | 0.83 | HDAC6 (0.49) | MEN1KMT2AHDAC6ESR2ESR1 | |
| SCHEMBL20047024 | 0.83 | CHRM5 (0.41) | MEN1KMT2AESR2ESR1OPRK1 | |
| SCHEMBL20047027 | 0.82 | PKM (0.51) | MEN1KMT2AESR2ESR1AKR1C3 | |
| SCHEMBL20047032 | 0.81 | KMT2A (0.47) | MEN1KMT2AESR2ESR1OPRK1 | |
| SCHEMBL20047021 | 0.81 | AKR1C3 (0.45) | MEN1KMT2AESR2ESR1OPRK1 | |
| SCHEMBL20047020 | 0.80 | MEN1 (0.40) | MEN1KMT2AESR2ESR1OPRK1 | |
| SCHEMBL20047030 | 0.78 | KMT2A (0.51) | MEN1KMT2AESR2ESR1OPRK1 | |
| SCHEMBL20047023 | 0.78 | AKR1C3 (0.49) | MEN1KMT2AOPRK1AKR1C3AKR1C1 | |
| SCHEMBL20047029 | 0.78 | CYP11B1 (0.50) | — | |
| SCHEMBL20047168 | 0.77 | OPRK1 (0.53) | MEN1KMT2AESR2ESR1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017223514-A9 | LXR INVERSE AGONISTS FOR TREATMENT OF CANCER | SAINT LOUIS UNIVERSITY (US) | 2018-04-12 | — | — | WO | disclosed |