Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20043197 | 0.83 | CHRNB2 (0.43) | ALDH1A1SMN1; SMN2HSD17B10CHRNB2CHRNA4 | |
| SCHEMBL20351887 | 0.83 | CHRNB2 (0.43) | ALDH1A1SMN1; SMN2HSD17B10CHRNB2CHRNA4 | |
| SCHEMBL20047644 | 0.83 | CHRNB2 (0.43) | ALDH1A1SMN1; SMN2HSD17B10CHRNB2CHRNA4 | |
| SCHEMBL4020718 | 0.80 | CTSD (0.39) | ALDH1A1SMN1; SMN2HSD17B10FKBP1ACHRNB2 | |
| SCHEMBL15443019 | 0.78 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL86929 | 0.76 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL62434 | 0.76 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL4030544 | 0.76 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2FKBP1ACHRNB2CHRNA4 | |
| SCHEMBL3942643 | 0.76 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2FKBP1ACHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL27884321 | 0.75 | SMN1; SMN2 (0.38) | ALDH1A1SMN1; SMN2CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10450306-B2 | Isoxazole analogs as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| US-20180099957-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. | 2018-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10450306-B2 | Isoxazole analogs as FXR agonists and methods of use thereof | GPBAR1, SLC10A1, NR1H4 | ALDH1A1 1577/4885SMN1; SMN2 4455/4885HSD17B10 572/4885 |
| US-20180099957-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | GPBAR1, SLC10A1, NR1H4 | ALDH1A1 1577/4885SMN1; SMN2 4455/4885HSD17B10 572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.