Sugi Predict

Sugi Predict / Compounds / SCHEMBL20048857

SCHEMBL20048857

SCHEMBL20048857

CO[S@@](=O)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.41
▸ HPGD P15428 2/20 0.39
▸ CA4 P22748 2/20 0.38
▸ EPHX1 P07099 1/20 0.34
▸ LMNA P02545 3/20 0.33
▸ PDE4B Q07343 1/20 0.33
▸ EPHX2 P34913 1/20 0.33
▸ F2 P00734 1/20 0.33
▸ CA12 O43570 1/20 0.33
▸ CA1 P00915 1/20 0.33
▸ CA2 P00918 1/20 0.33
▸ CA7 P43166 1/20 0.33
▸ CA9 Q16790 1/20 0.33
▸ CA14 Q9ULX7 1/20 0.33
▸ MAPT P10636 3/20 0.32
▸ RAB9A P51151 2/20 0.32
▸ CASP3 P42574 1/20 0.32
▸ SENP8 Q96LD8 1/20 0.32
▸ SENP7 Q9BQF6 1/20 0.32
▸ SENP6 Q9GZR1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21691195 1.00 TSHR (0.41) TSHRHPGDCA4EPHX1LMNA
SCHEMBL30306598 1.00 TSHR (0.41) TSHRHPGDCA4EPHX1LMNA
SCHEMBL950283 1.00 TSHR (0.41) TSHRHPGDCA4EPHX1LMNA
SCHEMBL29827611 0.97 TSHR (0.39) TSHRHPGDCA4EPHX1LMNA
SCHEMBL28529500 0.86 PDCD1 (0.40) TSHREPHX1LMNAPDE4BMAPT
SCHEMBL11052511 0.78 TSHR (0.33) TSHRHPGDEPHX1LMNAEPHX2
SCHEMBL30017163 0.78 TSHR (0.37) TSHRHPGDCA4EPHX1LMNA
SCHEMBL3088326 0.78 EPHX1 (0.37) TSHRHPGDEPHX1LMNAEPHX2
SCHEMBL12238362 0.77 ALDH1A1 (0.46) TSHRLMNACA1CA2CA9
SCHEMBL7717102 0.77 ALDH1A1 (0.46) TSHRLMNACA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11802110-B2 2-amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl-tRNA synthetase Oxford Drug Design Limited (GB) 2023-10-31 — — US disclosed
US-11802110-B2 2-amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl-tRNA synthetase Oxford Drug Design Limited (GB) 2023-10-31 — — US disclosed
CN-110049970-B 2-amino-N- (arylsulfinyl) -acetamide compounds as inhibitors of bacterial aminoacyl-TRNA synthase 牛津药物设计有限公司 2023-04-11 — — CN disclosed
US-20200039929-A1 2-AMINO-N-(ARYLSULFINYL)-ACETAMIDE COMPOUNDS AS INHIBITORS OF BACTERIAL AMINOACYL-TRNA SYNTHETASE INHIBOX LIMITED (GB) 2020-02-06 — — US disclosed
CN-110049970-A 2- amino-N- (aryl sulfonyl kia)-acetamide compound of inhibitor as bacterium aminoacyl-TRNA synzyme 牛津药物设计有限公司 2019-07-23 — — CN disclosed
WO-2018065611-A1 2-AMINO-N-(ARYLSULFINYL)-ACETAMIDE COMPOUNDS AS INHIBITORS OF BACTERIAL AMINOACYL-TRNA SYNTHETASE Oxford Drug Design Limited (GB) 2018-04-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11802110-B2 2-amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl-tRNA synthetase AARS1, NSUN3, GARS1 TSHR 1674/4885HPGD 3784/4885CA4 4753/4885
US-20200039929-A1 2-AMINO-N-(ARYLSULFINYL)-ACETAMIDE COMPOUNDS AS INHIBITORS OF BACTERIAL AMINOACYL-TRNA SYNTHETASE AARS1, NSUN3, GARS1 TSHR 1674/4885HPGD 3784/4885CA4 4753/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.