Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.33 |
| ▸ | NQO2 | P16083 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.32 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049056 | 0.84 | PDGFRB (0.37) | CSF1RCRHR1PDGFRBPDGFRANQO2 | |
| SCHEMBL20049120 | 0.83 | EGFR (0.33) | EGFRERBB2CRHR1PDGFRBPDGFRA | |
| SCHEMBL20049118 | 0.82 | ALPL (0.33) | TSHR | |
| SCHEMBL20049258 | 0.78 | AKR1C3 (0.31) | — | |
| SCHEMBL24345366 | 0.77 | MEN1 (0.39) | CRHR1PDGFRBPDGFRAALDH1A1SMN1; SMN2 | |
| SCHEMBL20049123 | 0.74 | CYP3A4 (0.33) | TSHR | |
| SCHEMBL20049330 | 0.70 | P2RX3 (0.44) | PDGFRBPDGFRAP2RX3P2RX2ALDH1A1 | |
| SCHEMBL23717026 | 0.70 | EGFR (0.38) | EGFRCRHR1P2RX3P2RX2ALDH1A1 | |
| SCHEMBL20047652 | 0.70 | ALPL (0.31) | PDGFRBPDGFRA | |
| SCHEMBL23905240 | 0.69 | P2RX3 (0.38) | CRHR1P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067704-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |