Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25749135 | 0.84 | NPC1 (0.38) | GAAHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20667373 | 0.82 | ALDH1A1 (0.39) | GAAHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11785426 | 0.82 | HSD17B10 (0.39) | HSD17B10NPC1RAB9ASMN1; SMN2SCN4A | |
| SCHEMBL20049190 | 0.82 | SMN1; SMN2 (0.42) | GAAHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12109865 | 0.82 | NPC1 (0.37) | GAAHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25492745 | 0.82 | RAB9A (0.37) | GAAHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21097668 | 0.80 | MAPT (0.48) | GAAHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23502448 | 0.80 | HSD17B10 (0.37) | HSD17B10NPC1RAB9ASMN1; SMN2SCN4A | |
| SCHEMBL21098342 | 0.77 | CHRNB2 (0.35) | GAAHSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25111970 | 0.77 | GAA (0.44) | GAAHSD17B10NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067704-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |