Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 16/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049873 | 0.88 | GRIN2B (0.52) | ALDH1A1L3MBTL1GRIN2BGRIN1PARP1 | |
| SCHEMBL25584017 | 0.85 | GRIN2B (0.40) | GRIN2BGAA | |
| SCHEMBL20049831 | 0.84 | GRIN2B (0.49) | ALDH1A1L3MBTL1GRIN2BGRIN1PARP1 | |
| SCHEMBL25587614 | 0.83 | GRIN2B (0.42) | GRIN2BGRIN1 | |
| SCHEMBL25587638 | 0.81 | ESR2 (0.46) | ALDH1A1GRIN2BGRIN1 | |
| SCHEMBL20049788 | 0.78 | GRIN2B (0.44) | GRIN2BGRIN1 | |
| SCHEMBL20049861 | 0.77 | GRIN2B (0.44) | GRIN2BGRIN1 | |
| SCHEMBL20049967 | 0.77 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1GRIN2BGRIN1PARP1 | |
| SCHEMBL20049822 | 0.76 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1GRIN2BGRIN1PARP1 | |
| SCHEMBL25587627 | 0.75 | GRIN2B (0.46) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523311-B1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-07 | — | — | EP | disclosed |
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |