Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 3/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25587614 | 0.88 | GRIN2B (0.42) | GRIN2BMAP4K4FYNEGLN1 | |
| SCHEMBL25587712 | 0.87 | GRIN2B (0.40) | GRIN2B | |
| SCHEMBL25583745 | 0.86 | GRIN2B (0.45) | GRIN2BPDGFRBPDGFRAMAP4K4CHEK2 | |
| SCHEMBL25587638 | 0.85 | ESR2 (0.46) | GRIN2BMAP4K4ESR2FYNEGLN1 | |
| SCHEMBL20049788 | 0.85 | GRIN2B (0.44) | GRIN2B | |
| SCHEMBL20049828 | 0.85 | ALDH1A1 (0.51) | GRIN2BGAA | |
| SCHEMBL20049966 | 0.84 | GRIN2B (0.43) | GRIN2BPDGFRBPDGFRA | |
| SCHEMBL25587774 | 0.83 | MAP4K4 (0.47) | GRIN2BPDGFRBPDGFRAMAP4K4ESR2 | |
| SCHEMBL25587627 | 0.82 | GRIN2B (0.46) | GRIN2B | |
| SCHEMBL20049896 | 0.81 | MKNK1 (0.43) | PDGFRBPDGFRAFYNCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523311-B1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-07 | — | — | EP | disclosed |