Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 9/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25584017 | 0.88 | GRIN2B (0.40) | GRIN2BMAP4K4EGLN1FYN | |
| SCHEMBL25587638 | 0.86 | ESR2 (0.46) | GRIN2BGRIN1MAP4K4EGLN1FYN | |
| SCHEMBL20049828 | 0.83 | ALDH1A1 (0.51) | GRIN2BGRIN1 | |
| SCHEMBL20049896 | 0.82 | MKNK1 (0.43) | FYN | |
| SCHEMBL20049844 | 0.82 | MAP4K4 (0.49) | GRIN2BGRIN1MAP4K4HSD17B1HSD17B2 | |
| SCHEMBL20049788 | 0.81 | GRIN2B (0.44) | GRIN2BGRIN1 | |
| SCHEMBL25587627 | 0.77 | GRIN2B (0.46) | GRIN2BGRIN1 | |
| SCHEMBL25587712 | 0.77 | GRIN2B (0.40) | GRIN2BGRIN1 | |
| SCHEMBL25583605 | 0.77 | NOS3 (0.39) | — | |
| SCHEMBL23319270 | 0.77 | EGLN1 (0.46) | GRIN2BGRIN1MAP4K4EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523311-B1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-07 | — | — | EP | disclosed |