Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 19/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049788 | 0.93 | GRIN2B (0.44) | GRIN2BGRIN1KCNH2 | |
| SCHEMBL25589007 | 0.87 | GRIN2B (0.43) | GRIN2BGRIN1 | |
| SCHEMBL20049829 | 0.86 | GRIN2B (0.41) | GRIN2BGRIN1KCNH2 | |
| SCHEMBL25584017 | 0.84 | GRIN2B (0.40) | GRIN2BPDGFRBPDGFRA | |
| SCHEMBL20049772 | 0.83 | GRIN2B (0.45) | GRIN2BGRIN1PDGFRBPDGFRAKCNH2 | |
| SCHEMBL25587712 | 0.82 | GRIN2B (0.40) | GRIN2BGRIN1 | |
| SCHEMBL25587638 | 0.80 | ESR2 (0.46) | GRIN2BGRIN1 | |
| SCHEMBL20049864 | 0.80 | GRIN2B (0.49) | GRIN2BGRIN1KCNH2 | |
| SCHEMBL25587614 | 0.80 | GRIN2B (0.42) | GRIN2BGRIN1 | |
| SCHEMBL20049785 | 0.78 | GPBAR1 (0.39) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523311-B1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-07 | — | — | EP | disclosed |
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |