Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049830 | 0.87 | EGLN1 (0.41) | MAP4K4GRIN1GRIN2BEGLN1WNT3A | |
| SCHEMBL20049838 | 0.87 | NPC1 (0.38) | GRM5GRIN1GRIN2BNPC1ALDH1A1 | |
| SCHEMBL20049775 | 0.86 | NPC1 (0.42) | PDGFRBPDGFRAGRIN1GRIN2BKDR | |
| SCHEMBL20049886 | 0.85 | PSMB5 (0.42) | GRM5MAP4K4GSK3AGSK3BKDR | |
| SCHEMBL20049984 | 0.85 | ESR2 (0.47) | GRM5MAP4K4GRIN1GRIN2BKDR | |
| SCHEMBL25584752 | 0.84 | GRIN2B (0.43) | GRIN1GRIN2B | |
| SCHEMBL20049967 | 0.84 | ALDH1A1 (0.52) | GRIN1GRIN2BALDH1A1L3MBTL1 | |
| SCHEMBL25588530 | 0.83 | NPC1 (0.36) | GRIN1GRIN2BNPC1ALDH1A1RAB9A | |
| SCHEMBL20049991 | 0.83 | PDGFRB (0.40) | PDGFRBPDGFRAGRIN1GRIN2BNPC1 | |
| SCHEMBL20049842 | 0.82 | NEK1 (0.43) | GRM5MAP4K4GSK3AGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523311-B1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-07 | — | — | EP | disclosed |
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |