Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 10/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004726 | 0.94 | OPRK1 (0.42) | ALOX5APALOX5CYP3A4CYP2C9OPRK1 | |
| SCHEMBL2004340 | 0.91 | F2RL3 (0.37) | ALOX5APOPRK1MAPTSMN1; SMN2 | |
| SCHEMBL2004657 | 0.91 | FAAH (0.38) | ALOX5APALOX5CYP3A4CYP2C9OPRK1 | |
| SCHEMBL2003878 | 0.90 | ALOX5AP (0.39) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL2004616 | 0.90 | ALOX5AP (0.42) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL2008229 | 0.90 | ALOX5AP (0.40) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL1999807 | 0.89 | ALOX5AP (0.42) | ALOX5APALOX5CYP3A4CYP2C9PTGS1 | |
| SCHEMBL2002574 | 0.89 | FAAH (0.42) | OPRK1MAPTKMT2A | |
| SCHEMBL2002177 | 0.88 | MAPT (0.38) | ALOX5APALOX5CYP3A4CYP2C9OPRK1 | |
| SCHEMBL2008081 | 0.88 | FAAH (0.41) | ALOX5APALOX5CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |