Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.37 |
| ▸ | FAAH | O00519 | 5/20 | 0.37 |
| ▸ | CES1 | P23141 | 5/20 | 0.37 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004657 | 0.94 | FAAH (0.38) | MAPTFAAHCES1NCEH1NPC1 | |
| SCHEMBL2002574 | 0.91 | FAAH (0.42) | MAPTALDH1A1FAAHCES1NCEH1 | |
| SCHEMBL2005704 | 0.91 | FAAH (0.39) | MAPTALDH1A1FAAHCES1NCEH1 | |
| SCHEMBL2008404 | 0.91 | L3MBTL1 (0.39) | MAPTPKMGAAALDH1A1S1PR3 | |
| SCHEMBL2004726 | 0.90 | OPRK1 (0.42) | MAPTPKMALDH1A1LMNAMEN1 | |
| SCHEMBL2004892 | 0.90 | LMNA (0.35) | MAPTPKMGAAALDH1A1S1PR3 | |
| SCHEMBL2004677 | 0.89 | MAPT (0.41) | MAPTPKMGAAALDH1A1S1PR3 | |
| SCHEMBL2007516 | 0.89 | S1PR3 (0.38) | MAPTPKMGAAALDH1A1S1PR3 | |
| SCHEMBL2004999 | 0.88 | ALOX5AP (0.40) | MAPTKMT2AOPRK1CYP3A4ALOX5 | |
| SCHEMBL2006137 | 0.88 | MAPT (0.42) | MAPTPKMGAAALDH1A1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |