Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25588082 | 0.84 | CHRNA7 (0.39) | ABL1CHRNA7GRIN1GRIN2BF2RL1 | |
| SCHEMBL20049904 | 0.81 | GRIN2B (0.42) | ABL1NPC1ALDH1A1GRIN1GRIN2B | |
| SCHEMBL20049775 | 0.79 | NPC1 (0.42) | ABL1NPC1ALDH1A1CHRNA7GRIN1 | |
| SCHEMBL20049838 | 0.74 | NPC1 (0.38) | ABL1NPC1ALDH1A1GRIN1GRIN2B | |
| SCHEMBL20050025 | 0.74 | CDK8 (0.39) | GRIN1GRIN2B | |
| SCHEMBL20049970 | 0.74 | GRM5 (0.43) | NPC1ALDH1A1GRIN1GRIN2BRAB9A | |
| SCHEMBL20049825 | 0.73 | GSK3B (0.42) | NPC1ALDH1A1GRIN1GRIN2B | |
| SCHEMBL20050027 | 0.73 | GRIN2B (0.44) | GRIN1GRIN2B | |
| SCHEMBL20049992 | 0.73 | CNR1 (0.39) | ABL1NPC1ALDH1A1GRIN1GRIN2B | |
| SCHEMBL25587881 | 0.72 | ABL1 (0.44) | ABL1NPC1ALDH1A1CHRNA7GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |