Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 20/20 | 0.71 |
| ▸ | IKBKE | Q14164 | 10/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.71 |
| ▸ | TTR | P02766 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.71 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19196681 | 0.87 | TBK1 (0.64) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL20693662 | 0.86 | TBK1 (0.69) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL19204321 | 0.86 | TBK1 (0.73) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL20694089 | 0.84 | TBK1 (0.81) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL6206524 | 0.83 | TBK1 (0.65) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL29642 | 0.83 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| SCHEMBL19182273 | 0.83 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL29441547 | 0.83 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL5058549 | 0.83 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 | |
| Amlexanox SCHEMBL29381739 | 0.83 | TBK1 (1.00) | TBK1IKBKEKDM4ENPC1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944652-B2 | Deuterated amlexanox | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-04-17 | — | — | US | disclosed |