Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25001373 | 0.79 | CYP2D6 (0.41) | CYP2D6SMN1; SMN2OPRM1OPRD1OPRK1 | |
| SCHEMBL18497937 | 0.78 | TSHR (0.46) | CYP2D6SMN1; SMN2CYP2C9TSHRALDH1A1 | |
| SCHEMBL18517451 | 0.75 | TSHR (0.38) | CYP2D6SMN1; SMN2OPRM1OPRD1OPRK1 | |
| SCHEMBL24940878 | 0.73 | CYP2D6 (0.37) | CYP2D6SMN1; SMN2OPRM1OPRD1OPRK1 | |
| SCHEMBL23126657 | 0.71 | MAPT (0.49) | CYP2D6SMN1; SMN2OPRM1OPRD1OPRK1 | |
| SCHEMBL18517454 | 0.71 | TSHR (0.50) | CYP2D6CYP2C9TSHRALDH1A1CYP3A4 | |
| SCHEMBL29326370 | 0.68 | CYP2D6 (0.38) | CYP2D6SMN1; SMN2OPRM1OPRD1OPRK1 | |
| SCHEMBL18517455 | 0.68 | CYP2D6 (0.43) | CYP2D6OPRM1OPRD1OPRK1CYP2C9 | |
| SCHEMBL23514830 | 0.68 | OPRM1 (0.39) | CYP2D6SMN1; SMN2OPRM1OPRD1OPRK1 | |
| SCHEMBL18517453 | 0.68 | TSHR (0.43) | CYP2D6CYP2C9TSHRALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944613-B2 | Fumagillol spirocyclic compounds and fused bicyclic compounds and methods of making and using same | ZAFGEN, INC. (US) | 2018-04-17 | — | — | US | disclosed |
| US-9944613-B2 | Fumagillol spirocyclic compounds and fused bicyclic compounds and methods of making and using same | ZAFGEN, INC. (US) | 2018-04-17 | — | — | US | disclosed |