Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2001856 | 0.94 | LMNA (0.36) | FAAHMEN1KMT2ALMNAMAPK1 | |
| SCHEMBL2004892 | 0.91 | LMNA (0.35) | FAAHMEN1KMT2AHTTLMNA | |
| SCHEMBL2004842 | 0.91 | FAAH (0.33) | FAAHLMNAMAPK1MAPTPTGDR2 | |
| SCHEMBL2007916 | 0.91 | LMNA (0.41) | FAAHMEN1KMT2ALMNAMAPK1 | |
| SCHEMBL2002574 | 0.90 | FAAH (0.42) | FAAHMEN1KMT2AHTTLMNA | |
| SCHEMBL2002542 | 0.90 | FAAH (0.49) | FAAHMEN1KMT2AHTTLMNA | |
| SCHEMBL2002818 | 0.90 | FAAH (0.44) | FAAHMEN1KMT2AHTTLMNA | |
| SCHEMBL2003878 | 0.89 | ALOX5AP (0.39) | MEN1KMT2ALMNAMAPK1ALOX5 | |
| SCHEMBL2007874 | 0.89 | FAAH (0.41) | FAAHMEN1KMT2AHTTPTGES2 | |
| SCHEMBL2002147 | 0.89 | ALDH1A1 (0.37) | MEN1KMT2ALMNAMAPK1PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |