Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.48 |
| ▸ | CYP4F2 | P78329 | 6/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 6/20 | 0.44 |
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21534646 | 0.99 | GPR119 (0.59) | GPR119HRH3CYP4F2CYP4A11RBP4 | |
| SCHEMBL20053595 | 0.94 | GPR119 (0.53) | GPR119HRH3HPGDSHPGD | |
| SCHEMBL15539154 | 0.92 | GPR119 (0.53) | GPR119HRH3CYP4F2CYP4A11HPGDS | |
| SCHEMBL15538941 | 0.92 | GPR119 (0.53) | GPR119HRH3CYP4F2CYP4A11HPGDS | |
| SCHEMBL15538942 | 0.92 | GPR119 (0.53) | GPR119HRH3CYP4F2CYP4A11HPGDS | |
| SCHEMBL20053540 | 0.91 | GPR119 (0.56) | GPR119HRH3CYP4F2CYP4A11RBP4 | |
| SCHEMBL15537842 | 0.91 | GPR119 (0.54) | GPR119HRH3CYP4F2CYP4A11RBP4 | |
| SCHEMBL15539091 | 0.90 | GPR119 (0.55) | GPR119HRH3CYP4F2CYP4A11HPGDS | |
| SCHEMBL15540121 | 0.90 | GPR119 (0.55) | GPR119HRH3CYP4F2CYP4A11HPGDS | |
| SCHEMBL15539088 | 0.90 | GPR119 (0.55) | GPR119HRH3CYP4F2CYP4A11HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858986-B1 | PIPERIDINE DERIVATIVES AS GPR119 AGONISTS | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2019-10-30 | — | — | EP | disclosed |
| US-9944600-B2 | Piperidine derivatives for GPR119 agonist | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2018-04-17 | — | — | US | disclosed |