Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.39 |
| ▸ | FEN1 | P39748 | 3/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.39 |
| ▸ | ATR | Q13535 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15538518 | 0.92 | ALOX5AP (0.46) | GPR119ALOX5APFEN1PIK3CAMTOR | |
| SCHEMBL15538520 | 0.92 | ALOX5AP (0.46) | GPR119ALOX5APFEN1PIK3CAMTOR | |
| SCHEMBL21535164 | 0.92 | GPR119 (0.43) | GPR119ALOX5APFEN1ATRDYRK1A | |
| SCHEMBL15539321 | 0.92 | ALOX5AP (0.46) | GPR119ALOX5APFEN1PIK3CAMTOR | |
| SCHEMBL15539317 | 0.90 | ALOX5AP (0.44) | GPR119ALOX5APFEN1ATRPIK3CA | |
| SCHEMBL15538833 | 0.90 | ALOX5AP (0.44) | GPR119ALOX5APFEN1ATRPIK3CA | |
| SCHEMBL15539379 | 0.90 | GPR119 (0.45) | GPR119ALOX5APFEN1DYRK1ADGAT1 | |
| SCHEMBL20053537 | 0.89 | DYRK1A (0.41) | GPR119DYRK1APIK3CAMTORHCRTR1 | |
| SCHEMBL20053576 | 0.88 | GPR119 (0.58) | GPR119NR3C1 | |
| SCHEMBL20053643 | 0.88 | GPR119 (0.43) | GPR119NR3C1PIK3CAMTORHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858986-B1 | PIPERIDINE DERIVATIVES AS GPR119 AGONISTS | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2019-10-30 | — | — | EP | disclosed |
| US-9944600-B2 | Piperidine derivatives for GPR119 agonist | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2018-04-17 | — | — | US | disclosed |