Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CPS1 | P31327 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15538905 | 0.92 | PIK3CA (0.41) | GPR119NR3C1PDK1PDK2PDK3 | |
| SCHEMBL15538907 | 0.92 | PIK3CA (0.41) | GPR119NR3C1PDK1PDK2PDK3 | |
| SCHEMBL15538258 | 0.90 | GPR119 (0.43) | GPR119PDK1PDK2PDK3PDK4 | |
| SCHEMBL20053726 | 0.88 | GPR119 (0.45) | GPR119NR3C1METMTORPIK3CA | |
| SCHEMBL20053537 | 0.87 | DYRK1A (0.41) | GPR119METKCNH2HRH3CPS1 | |
| SCHEMBL20053741 | 0.87 | GPR119 (0.44) | GPR119NR3C1HRH3BCHEACHE | |
| SCHEMBL15539062 | 0.87 | CNR2 (0.39) | GPR119NR3C1PDK1PDK2PDK3 | |
| SCHEMBL15539058 | 0.87 | CNR2 (0.39) | GPR119NR3C1PDK1PDK2PDK3 | |
| SCHEMBL20053576 | 0.87 | GPR119 (0.58) | GPR119NR3C1CPS1 | |
| SCHEMBL15539069 | 0.87 | GPR119 (0.41) | GPR119PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858986-B1 | PIPERIDINE DERIVATIVES AS GPR119 AGONISTS | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2019-10-30 | — | — | EP | disclosed |
| US-9944600-B2 | Piperidine derivatives for GPR119 agonist | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2018-04-17 | — | — | US | disclosed |