Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 5/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | WNT1 | P04628 | 1/20 | 0.53 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | HTR1F | P30939 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10352589 | 0.90 | ACVRL1 (0.61) | PIK3C3GSK3BMEN1KMT2AALDH1A1 | |
| SCHEMBL12460810 | 0.88 | MAPK8 (0.67) | PIK3C3GSK3BDYRK1AMEN1KMT2A | |
| SCHEMBL13922555 | 0.87 | SMN1; SMN2 (0.61) | GSK3BMEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL25131241 | 0.86 | GSK3B (0.50) | PIK3C3GSK3BDYRK1AMEN1KMT2A | |
| SCHEMBL13922554 | 0.85 | SMN1; SMN2 (0.64) | GSK3BMEN1KMT2AALDH1A1ALOX15 | |
| SCHEMBL18170428 | 0.84 | PIK3C3 (0.56) | PIK3C3GSK3BDYRK1AABL1WNT1 | |
| SCHEMBL4339961 | 0.84 | ALDH1A1 (0.60) | PIK3C3GSK3BDYRK1AALDH1A1ABL1 | |
| SCHEMBL29676896 | 0.84 | PIK3C3 (0.56) | PIK3C3GSK3BDYRK1AABL1WNT1 | |
| SCHEMBL29012701 | 0.84 | GSK3B (0.54) | PIK3C3GSK3BDYRK1AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL21640572 | 0.80 | LMNA (0.51) | GSK3BDYRK1AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357921-A2 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | Sunesis Pharmaceuticals, Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-3080103-B1 | BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY | BIOGEN MA INC (US) | 2018-04-18 | — | — | EP | disclosed |