Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20056636 | 0.83 | ESR2 (0.53) | ESR2TLR8CXCL12 | |
| SCHEMBL14599496 | 0.75 | HSD17B1 (0.52) | ESR2TLR8HSD17B1HSD17B2MGAM | |
| SCHEMBL15929639 | 0.74 | HSD17B1 (0.50) | ESR2FYNHSD17B1HSD17B2GAA | |
| Ethane SCHEMBL27954414 | 0.74 | MAOB (0.53) | ESR2FYNCXCL12HSD17B1HSD17B2 | |
| SCHEMBL20056359 | 0.73 | ESR2 (0.50) | ESR2FYNHSP90AA1HSP90AB1ESR1 | |
| SCHEMBL23496933 | 0.73 | TLR8 (0.52) | ESR2TLR8FYNHSD17B1HSD17B2 | |
| SCHEMBL30719599 | 0.73 | TLR8 (0.52) | ESR2TLR8FYNHSD17B1HSD17B2 | |
| SCHEMBL20056607 | 0.73 | KDM1A (0.52) | TLR8 | |
| Ethane SCHEMBL27714634 | 0.70 | TLR8 (0.59) | ESR2TLR8HSD17B1HSD17B2GAA | |
| SCHEMBL28294685 | 0.70 | MGAM (0.49) | ESR2TLR8FYNHSP90AA1ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970353-B1 | MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | VERTEX PHARMA (US) | 2018-04-18 | — | — | EP | disclosed |