Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | RGS12 | O14924 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | PTGES | O14684 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003631 | 0.89 | LMNA (0.68) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL2996259 | 0.89 | PTGDR2 (0.60) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5454133 | 0.87 | LMNA (0.63) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5439155 | 0.87 | LMNA (0.65) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL14438055 | 0.86 | LMNA (0.51) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL2006373 | 0.84 | LMNA (0.69) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL2003800 | 0.84 | LMNA (0.71) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL15062617 | 0.84 | PTGDR2 (0.49) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL2003959 | 0.83 | PLA2G2A (0.50) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5439170 | 0.83 | LMNA (0.65) | LMNACYP1A2CYP3A4CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |