Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | RGS12 | O14924 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
| ▸ | PTGES | O14684 | 1/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.62 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5441051 | 0.93 | LMNA (0.56) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5438065 | 0.93 | LMNA (0.56) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5435406 | 0.92 | PLA2G2A (0.63) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5439170 | 0.91 | LMNA (0.65) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5444375 | 0.91 | PTGS2 (0.65) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL3003631 | 0.90 | LMNA (0.68) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5437577 | 0.89 | LMNA (0.70) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5454133 | 0.88 | LMNA (0.63) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5447435 | 0.88 | PTGDR2 (0.58) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL5444376 | 0.88 | PTGDR2 (0.58) | LMNACYP1A2CYP3A4CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20100197708-A1 | INDOLE COMPOUNDS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2010-08-05 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
| US-20090118503-A1 | FAAH INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. | 2009-05-07 | — | — | US | disclosed |
| US-20070203209-A1 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. | 2007-08-30 | — | — | US | disclosed |
| US-20070203209-A1 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. | 2007-08-30 | — | — | US | disclosed |
| US-20070161698-A1 | Modulators of CRTH2 Activity | MICROBIA, INC. | 2007-07-12 | — | — | US | disclosed |
| US-7205329-B2 | Modulators of CRTH2 activity | MICROBIA, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| WO-2007022501-A2 | USEFUL INDOLE COMPOUNDS | MICROBIA, INC. (US) | 2007-02-22 | — | — | WO | disclosed |
| US-20060135591-A1 | Modulators of CRTH2 activity | IRONWOOD PHARMACEUTICALS, INC. | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135591-A1 | Modulators of CRTH2 activity | HRH2, HRH1, MRGPRX2 | LMNA 4458/4885CYP1A2 2697/4885CYP3A4 4306/4885 |
| US-20070161698-A1 | Modulators of CRTH2 Activity | HRH2, HRH1, MRGPRX2 | LMNA 4458/4885CYP1A2 2697/4885CYP3A4 4306/4885 |
| US-20100197708-A1 | INDOLE COMPOUNDS | IDO1, IDO2, TPH2 | LMNA 3450/4885CYP1A2 287/4885CYP3A4 374/4885 |
| US-20070203209-A1 | Useful indole compounds | TPH2, HRH2, HRH1 | LMNA 4592/4885CYP1A2 672/4885CYP3A4 2655/4885 |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | FAAH, FAAH2, AANAT | LMNA 4536/4885CYP1A2 360/4885CYP3A4 618/4885 |
| US-20090118503-A1 | FAAH INHIBITORS | FAAH, FAAH2, CNR2 | LMNA 4089/4885CYP1A2 302/4885CYP3A4 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.