Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20058379 | 0.82 | KDM4E (0.45) | EPHX2MAPK1SMN1; SMN2HTTMEN1 | |
| SCHEMBL19107360 | 0.82 | MEN1 (0.48) | EPHX2GPR183MEN1KMT2A | |
| SCHEMBL9364495 | 0.76 | EPHX2 (0.77) | EPHX2SMN1; SMN2HTTPOLBLMNA | |
| SCHEMBL17318817 | 0.75 | L3MBTL1 (0.42) | SIGMAR1 | |
| SCHEMBL20153274 | 0.74 | LMNA (0.50) | EPHX2MAPK1SMN1; SMN2HTTPOLB | |
| SCHEMBL17868397 | 0.74 | HSD11B1 (0.53) | EPHX2GPR183SMN1; SMN2POLBMEN1 | |
| SCHEMBL18785481 | 0.74 | TSHR (0.47) | POLBLMNACYP2D6NPC1TP53 | |
| SCHEMBL20058380 | 0.73 | L3MBTL1 (0.55) | EPHX2MAPK1SMN1; SMN2CYP2D6ALDH1A1 | |
| SCHEMBL22305103 | 0.70 | CA12 (0.71) | EPHX2SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL6985975 | 0.70 | CA12 (0.71) | EPHX2SMN1; SMN2POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3149005-B1 | AMIDE DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE LABOR DR (ES) | 2018-04-18 | — | — | EP | disclosed |