Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | VDR | P11473 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14499049 | 0.81 | NOTUM (0.62) | ALDH1A1HTTMEN1LMNAKMT2A | |
| SCHEMBL9576840 | 0.81 | ALDH1A1 (0.60) | ALDH1A1HTTVDRMEN1LMNA | |
| SCHEMBL654774 | 0.79 | SMN1; SMN2 (0.67) | ALDH1A1HTTMEN1LMNAKMT2A | |
| SCHEMBL29966790 | 0.79 | SMN1; SMN2 (0.67) | ALDH1A1HTTMEN1LMNAKMT2A | |
| SCHEMBL11130277 | 0.79 | NOTUM (0.60) | ALDH1A1HTTMEN1LMNAKMT2A | |
| SCHEMBL7018054 | 0.79 | NOTUM (0.60) | ALDH1A1HTTMEN1LMNAKMT2A | |
| SCHEMBL7708593 | 0.79 | ALDH1A1 (0.59) | ALDH1A1HTTVDRLMNAKMT2A | |
| SCHEMBL7862085 | 0.79 | NOTUM (0.53) | ALDH1A1HTTMEN1LMNAKMT2A | |
| SCHEMBL7702916 | 0.79 | ALDH1A1 (0.59) | ALDH1A1HTTVDRLMNAKMT2A | |
| SCHEMBL12868260 | 0.79 | VDR (0.70) | ALDH1A1VDRMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794556-B1 | BIS-(ARYL/HETEROARYL)-METHYLENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THEIR USE FOR TREATING CANCER | GLEASON JAMES L (CA) | 2018-04-18 | — | — | EP | disclosed |